There is currently no cure for histamine intolerance.

The key to success is for the patient to learn to adjust to a low-histamine diet and manage the condition(s) until it either goes away, or for life.

The patient needs to avoid stress.

Symptoms can be alleviated (but this is not the overall solution!) with the help of the following options:

ANTIHISTAMINES:

H1, H2, H3, H4,… receptor blockers according to the symptoms of the patient.

DAO ENZYME SUPPLEMENTS:

The same product under different commercial names is available, but in the UK, at the time of writing, is only available via the internet. Success rates are variable depending on the usage and personal threshold of the individual patient. However, there have been reports of successful therapy with the help of this DAO supplement, independently of those reports given for PR purposes by the product’s manufacturer.

VITAMIN AND MINERAL SUPPLEMENTS:

Following supplements have been suggested. It is however advisable to try to ingest these elements by eating foods that contain them and only to resort to taking supplements when absolutely necessary and in accordance with the doctor’s advice or that of a dietician:

  • Vitamin C: lowers the histamine level in the blood
  • Vitamin B6: is an important co-factor of the enzyme diamine oxidase and its activity
  • Calcium: reduces the development of wheals and flushing of the skin
  • Zinc: has anti-allergic and anti-inflammatory properties and constrains histamine release
  • Copper: is able to elevate the plasma level of DAO slightly
  • Magnesium: a Magnesium deficit lowers the allergic reaction threshold
  • Manganese: elevates diamine oxidase activity [viii]
  • Vitamin B1
  • Vitamin B12
  • Folic Acid [ix]

DRUGS THAT IMPAIR DIAMINE OXIDASE (DAO) ACTIVITY  (Go back to top)

Some drugs interfere with the DAO enzyme, reducing its activity:

ACTIVE INGREDIENT NAME
Aminophylline Phyllocontin, Uniphyllin, Nuelin, Slo-Phyllin
Amitriptyline Triptafen
Chloroquine Avloclor, Malarivon, Nivaquine, Paludrine/Avloclor
Clavulanic Acid Augmentin, Co-amoxiclav
Isoniazid
Metoclopramide Maxalon, Paramax
Propafenone Arythmol
Verapamil Cordilox, Securon
Anti-inflammatory/painkilling drugs can increase histamine release in allergy sufferers
ACTIVE INGREDIENT NAME
Mefenamic acid Ponstan,
Diclofenac Voltarol, Dicloflex, Diclomax, Motifene, Arthrotec
Indometacin Indacid, Rimacid
Flurbiprofen Froben
Naproxen Naprosyn, Synflex, Napratec, Arthroxen
Ketoprofen Orudis, Oruvail
Acetylsalicylic acid Aspirin, Caprin, Anadin and many others

[viii]Patienteninformation, Histaminunverträglichkeit, Histaminintoleranz, Facharztpraxis Labor Doz. Schön, pg. 11

[ix]Jarisch pg 90: „Um eine ausreichende Aktivität der histaminabbauenden Enzyme (Diamineoxidase) zu erreichen, sollte neben den üblichen Aspekten für eine gesunde Ernährung auf eine ausreichende Zufuhr von Vitamin B1, Vitamin B12, Folsäure, Kupfer und Vitamin C geachtet werden.“

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